Academisch Ziekenhuis Leiden

LUMC is a university medical center for research, education and patient care with a high quality profile and a strong scientific orientation. LUMC is centre for medical innovation and offers state-of-the-art research facilities. LUMC participates in the League of European Research Universities (LERU), as well as Eurolife, EIT Health, and other international research alliances.

The Department of Cardiology is a high volume, national and international referral center for the treatment of complex ventricular arrhythmias, performing approximately 180 VT catheter ablation per year. Radiation oncology at LUMC is an academic Radiation Oncological Department in two locations with access to brachytherapy, image guided photon and proton RT.

One of the main research lines of the departments is the integration of multimodal data sets to guide catheter ablation of complex ventricular arrythmias. LUMC has developed a method of real-time registration of invasive electroanatomical mapping data and multimodal cardiac imaging (CT and CE-CMR) validated by whole heart histology to accurately define, delineate and register segmented scars and related VT substrates with registration errors of less than 2.0±0.3mm in humans in-vivo and in animal models. This workflow, with related software packages, has been successfully applied during routine catheter procedures for many years. In collaboration with IKEM, LUMC has adapted and further developed the workflow for data transfer to the planning CT with promising pilot data.